We fundamentally disagree with the position that the search for common variants associated with psychopathology is no longer relevant. Gene discovery, for disorders with moderate and high heritability, continues to be essential from two perspectives: mechanistic insight, and treatment improvement. Indeed, GWAS would be less appealing if research were to cease at gene discovery. This is rarely the case. However, the progress from discovery and replication of a locus to the outline of its etiologic significance takes time, resources, and collaborative interdisciplinary science (International Schizophrenia et al., 2009, Sekar et al., 2016).
