similar fashion, positive euphoric effects of alcohol can be modulated by epigenetic changes in the reward circuitry and HDAC inhibitors can reverse HDAC-induced adaptational mechanisms during alcohol withdrawal (Arora et al., 2013). Thus by affecting both the positive and negative states that arise due to alcohol exposure and withdrawal, HDAC inhibition holds great promise as an effective therapeutic option to treat alcoholism and also to further understand the epigenetic alterations that underlie the pathogenesis of alcoholism.
