The miRNA and mRNA hub genes from the modules significantly correlated with AD were correlated (Pearson product moment) with each other. Since one sample was removed from the mRNA arrays, for the correlation analysis the same sample was removed from the miRNA arrays as well. In the correlation procedure, we focused only on the negative miRNA:mRNA MEs correlations, as these represent the direct, gene silencing effects of miRNAs on their targets, and the significant negative correlations were adjusted at a FDR ≤0.10.
