The functional coupling theme of a specific subregion driving the DMN−networks correspondence was also observed in other modes for the precuneus (PMC-1) and lateral portion of the ventromedial prefrontal DMN (vmPFC-2) (SI Appendix, Figs. S3–S6). In the second most important mode (r = 0.77), the precuneus showed increased coupling with most DMN subregions. Concurrently, at the network integration level, the DMN disengaged with the saliency network, analogous to mode 1, and showed decreased coupling with somatosensory cortices, dlPFC, dorsal attention networks, and lateral visual cortex. In mode 9 (r = 0.66), the lateral subregions of the right vmPFC similarly increased coupling with most DMN subregions. In this mode, the ventral attention network was disengaged with the dorsal attention network, posteromedial cortices, and dlPFC, while the saliency network was decoupled from parietal cortices and was increased in coupling with dorsal attention network and dlPFC. We conclude that DMN subregions in the anterior TPJ, precuneus, and lateral vmPFC appear to play particularly important roles related to the functional interplay between large-scale networks.
