In another recent study by Criado and Ehlers [171], EROs in selectively bred adult alcohol-preferring (P) and alcohol-non preferring (NP) rats were compared. While the previous electrophysiological studies have shown P rats exhibited more EEG fast frequency activity and reduced P3 amplitude in the parietal cortex than NP rats [173], findings that are more common in alcohol-dependent individuals, the authors tested the possibility that EROs could be excellent endophenotypes associated with ethanol dependence using similar animal. The findings confirmed that the decrease in P3 amplitudes previously shown in P rats were significantly associated with decreases in evoked delta and alpha/beta phase locking. These findings in animal models of alcoholism further confirmed the findings of human studies that that ERO measures provide good endophenotypes in the study of alcoholism.
