If AAs are to have equal opportunity to make decisions about undergoing ES/WGS and or realize benefits from receiving ES/WGS results, the distrust that results from past experiences of AAs in research and clinical practice, the realities of current health and health care disparities, culturally based health beliefs, and the social structures of AA communities must be considered in building infrastructure for the translation of ES/WGS and results return. This will require a synthesis of innovative strategies for results management and for culturally appropriate communication of health information.
