Chunk #26 — Introduction — 1. Epigenetic Regulation due to Histone Covalent Modifications — 1E. Other Drugs of Abuse and Histone Acetylation and Deacetylation Mechanisms
of HDAC activity has also been implicated in enhancement of morphine-induced locomotor sensitization and conditioned place preference (Sanchis-Segura, Lopez-Atalaya, & Barco, 2009) and in nicotine preference (Pastor, Host, Zwiller, & Bernabeu, 2011). All these studies emphasize the complexity of HDAC inhibition and bring into context the different variables that have to be addressed such as the dosage of the drug, brain region studied, class and dosage of HDAC inhibitor, timing of administration and innate genetic differences in the employed animal models. Examinations of HDAC mediated pathways in ethanol and cocaine studies reveal the importance of understanding the regulation and mode of action of HDACs in order to advance the field of addiction and develop appropriate therapeutic interventions.
