longer observed a clear excess of P values smaller than expected by chance (Fig. 1c). One might conclude from this that few detectable BMI loci remain to be found. However, we are encouraged in further pursuit because among the remaining data are two additional loci reported by Thorleifsson et al. (BDNF and ETV5); both of these loci show strong confirming evidence for association in our stage 1 meta-analysis (P values of 0.00035 and 0.00043).
