SNP8^T/T in CD cases was significantly higher than in controls among subjects carrying SNP3^G; Logistic regression analysis showed that the interaction between SNP3^G+ and SNP8^T/T significantly increased the risk for CD; and haplotypewise analysis also consistently showed that the GT haplotype (constructed from SNP3^G and SNP8^T) increased risk for CD (P=0.018). Finally, as shown in Figure 2, both SNP8 and a SNP8-linked SNP, i.e., SNP6, showed nominally significant association signals, but the other SNPs did not, which also argues against a false positive association at the SNP8 locus.
