Given the higher rates of SA observed among those with AUD, we explored whether there are clinical, genomic, and neurophysiological markers of SA within this population. Among participants diagnosed with DSM-IV Alcohol Dependence (AD) drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), we first conducted a genome-wide association study (GWAS) of SA and performed downstream analyses to determine whether we could identify specific biological pathways of risk. Next, to explore risk in aggregate, we examined whether clinical risk factors, polygenic scores (PGS) for comorbid psychiatric problems, and neurocognitive functioning differed between those with AD who have and have not reported a lifetime suicide attempt.
