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Chunk #15 — Materials and methods — Statistical analysis

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Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.
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The Yale-Penn results for CD and OD in EAs, AAs, and the combined meta-analyses were uploaded to the Functional Mapping and Annotation (FUMA) of GWAS portal [42], which performs functional mapping, gene based tests, and gene set enrichment analyses using GWAS summary statistics. Regional Manhattan plot were generated using Locuszoom software [43].