In sum, we show that depression is characterized by elevated within-DMN and DMN-FPN phase synchronization in the beta-band, which normalizes to some extent following symptom remission but is associated with a more recurrent depressive illness course. Excessive beta-band synchronization, which has been associated with maintaining the brain’s ‘status quo’, may be a mechanism that drives DMN inflexibility in depressed individuals. These findings highlight measures of EEG source functional connectivity as powerful tools for investigating the spectral signatures of connectivity disturbances in psychopathology.
