was supported by simulation results from clinical EEG data. In this study, we examined the effect of recording reference on commonly used quantitative methods for measuring neuronal synchrony. Using analytical methods, simulations, and experimental results from a patient with intracranial and scalp electrodes, we investigated the effect of recording reference signal on common measures of neuronal synchrony. We demonstrated the significant impact that the recording reference has on these measures and how this can be overcome [1]. In this paper, we conducted one subject analysis which fully supports our theoretical results. Based on the analytical, simulation, and experimental results from a human recording, we are confident that the interpretation of the reference-signal effect on these three measures is correct. In the future, we will apply corrected EEGs (or iEEGs) obtained in real time to disclose real neural synchronization which may shed new light in real-world applications, such as seizure prediction, seizure source localization, and brain–computer interface.
