GWAS catalog data for the 109 pleiotropic risk loci showed enrichment of implicated genes in a range of brain-related traits (Table S7.2). As expected, the associated traits included SCZ, BIP, and ASD. In addition, the pleiotropic risk loci were enriched among genes previously associated with neuroticism (corrected enrichment p= 5.28×10−6; GRIK3, CTNND1, DRD2, RGS6, RBFOX1, ZNF804A, L3MBTL2, CHADL, RANGAP1, RSRC1, GRM3), cognitive ability (corrected p= 7.15×10−5; PTPRF, NEGR1, ELOVL3, SORCS3, DCC, CACNA1I), and night sleep phenotypes (corrected p= 1.86×10−2; PBX1, NPAS3, RGS6, GRIN2A, MYO18A, TIAF1, CNTN4, PPP2R2B, TENM2, CSMD1). We also found significant enrichment of pleiotropic risk genes in multiple measures of body mass index (BMI), supporting previous studies suggesting a shared etiologic basis between a range of neuropsychiatric disorders and obesity (Hartwig et al., 2016; Lopresti and Drummond, 2013; Milaneschi et al., 2018).
