Chunk #16 — Results — Total CHRNA5 mRNA level in frontal cortex is strongly associated with variants located upstream of the gene in individuals of both African and European ancestry
effect of rs3841324, the association of rs880395 with CHRNA5 mRNA expression remains statistically significant in samples of African ancestry (p = 1.79×10−5) and in samples of European ancestry (p = 1.99×10−3). Similarly, conditional analysis showed rs880395 remains significantly associated with CHRNA5 expression in both samples of African ancestry (p = 1.86×10−5) and European ancestry (1.38×10−5) after controlling for the effect of rs588765.
