Differences across groups were evaluated by using Chi-square statistics for categorical data and one-way analysis of variance (ANOVA) for continuous variables. Scheffé post hoc tests were used to determine significant differences in specific group comparisons. To compare characteristics of continuous variables over time, repeated measurement ANOVA (MANOVA) was used. For post-hoc group comparisons, Scheffé post-hoc tests were employed, when applicable. Group 2 and 4 individuals were compared for characteristics of CUDs while Group 1 and 3 members (per definition no CUD) were skipped from these analyses.
