The above data indicate a) suicide is strongly associated with current smoking; however, whether this is because smoking is a marker for other causes of suicide or because smoking or nicotine actually is a behavioral toxin is unclear, b) suicide might be expected to increase during initial smoking cessation but the little data available does not confirm this, and c) three smoking cessation medications--bupropion, rimonabant and varenicline--have been associated with suicidality in smokers; however, the validity of data for this last association is unclear.
