might increase the relative contribution of genetic variation to alcohol intake and, on the other; pregnancy might result in metabolic changes and modify the effect of the ADH1B and other ADH variants. A systematic review on the incidence of fetal alcohol syndrome in populations of European and African origins found that this SNP was associated with offspring outcome (33), but highlighted the need to better understand the extent to which the ADH1B variant is associated with prenatal alcohol use (33).
