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Chunk #45 — Discussion — Novelty P3 and the CSD-PCA Factor Structure for the Novelty Oddball Task

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
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ICA, which separated an anterior from a posterior cluster. The anterior cluster corresponded, in part, to a midline frontocentral novelty P3, whereas the posterior cluster reflected aspects of parietal P3b. As reflected in single-trial and split-half plots, nontarget novelty P3 in the frontocentral cluster decreased over trials, the decreases being most prominent at latencies longer than the novelty P3 peak. In contrast, when novels were used as targets, frontocentral P3 was generally enhanced, with no evidence of habituation.