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Chunk #5 — Introduction

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Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study.
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The study presented here was designed as a replication and extension of the Sakai (2010) study, which found some evidence for association with adolescent CD in a subset of the Colorado Center on Antisocial Drug Dependence (CADD) sample (although it did not survive statistical correction for multiple testing). In the current study, the sample size has been expanded and an independent replication sample is now available. We now have an additional wave of data collection; thus adolescent alcohol problems and CD could be evaluated at the first wave of data collection (adolescence and young adulthood) and alcohol abuse and dependence (AAD) subsequently examined in the second wave of data collection (adulthood).