As an additional global measure of power, we considered the number of significantly enriched pathways for a large number of GWAS meta-analysis summary statistics. On average, our approach resulted in higher numbers of significant pathway scores than any binary enrichment strategy. Given its precise type I error control, this provides additional evidence of increased power for a wide range of traits. Indeed, the elevated rate of putatively involved pathways produced by our method not only reflects its higher sensitivity, but also already generates new hypotheses for further studies.
