As noted above, AD is characterized by a progressive decline in cognition (e.g., memory, stimulus processing) and other behavioral functions (e.g., anxiety, fear). Importantly, cognitive decline in conjunction with comorbid neuropsychiatric conditions such as anxiety may reflect early stages of AD pathology (Buckley et al., 2016; Jessen et al., 2014). Evidence indicates that 3xTg-AD mice exhibit a variety of behavioral phenotypes consistent with progressive cognitive decline and altered emotional state in a manner that is associated with development of underlying neural pathology (Filali et al., 2012; Huber et al., 2018; Pietropaolo et al., 2014; Romano et al., 2014; Webster et al., 2014).
