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Chunk #94 — Online Methods — Selection of datasets

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Absolute quantification of somatic DNA alterations in human cancer.
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We analyzed 2445 Affymetrix 250 K Sty SNP samples from a previous pan cancer survey 35 containing 3131 cancer samples. Because our processing of the data required use of the Birdseed algorithm 59, external datasets lacking diploid PCR controls could not be used. In addition, cancer types with fewer than 20 samples were excluded. In addition, 680 Affymetrix SNP6.0 samples were taken from the TCGA GBM 21 and HGS-OvCa 33 studies, as well as 30 cell-line samples, bringing to total sample count to 3155. The complete table of cancer samples analyzed is available as Supplementary file 1. The complete table of ABSOLUTE results is available as Supplementary file 2.