Under the baseline parameter settings (see Methods) it is seen that the CMC method, as reported in [26], has better performance than the variant-by-variant and CAST methods, but the weighted sum method has even better performance (Figure 2). The weighted-sum method identifies groups with a PAR of 10%, with at least 80% power, for all genetic models (Figure 2). To investigate whether the weighted-sum method is robust under other model parameters, we fix the group PAR at 10%, and vary the other parameters one by one.
