The alternative spliced PPP3CA variants include or delete exons in this region of that might exert significant differences in PPP3CA function with unique patterns of brain and/or peripheral tissue expression, in manners that suggest specific regulation. CNEX13-15 appears to be selectively preserved in mRNAs from postmortem AD brains in ways that support the specificity of effects on other PPP3CA transcripts and might even suggest that this CNEX13-15 isoform might be expressed by different cell types.
