On the other hand, the studies that assessed common variation and haplotypes in the CRP gene with plasma CRP levels differed in SNP selection methodology and estimated haplotypes.[9], [16], [22]–[24], [32], [37] For example, Carlson et al.[32] resequenced 47 samples from panels with African American and European descent individuals to select seven tagging SNPs for eight haplotypes in the CARDIA study. On the other hand, Miller et al.[23] resequenced 192 individuals in the Women's Health Study with extreme discordant baseline CRP levels and selected seven tagging SNPs for six common haplotypes among Caucasians participants in three sub-cohorts. In the Rotterdam Study, Kardys et al. genotyped 3 tagging SNPs (3014, 3872, and 4741) selected from SeattleSNPs which were sufficient to infer four common haplotypes.[22] Though overall haplotypes were not exactly replicated, the more recent studies shared much overlap in selected SNPs. Based on LD patterns and similar reference groups, our results were similar to what has been previously reported. The haplotypes associated with lower CRP levels were similar, as were the haplotypes associated with higher CRP levels.
