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Chunk #75 — 5. Procedures for evaluating pharmacological treatments targeting alcohol abuse and dependence — 5.9. Summary

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.
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or “too much too often” need to be factored into individualized treatment strategies and the development of animal models of alcoholism. The drinking-in-the-dark scheduled access (e.g., Bell et al., 2011; Crabbe et al., 2009) and alcohol deprivation effect (c.f., Rodd et al., 2004b) procedures appear to mimic the former and latter respectively. Finally, the relatively crude level of measurement (Heilig and Koob, 2007: g/kg/unit time) and the inability to measure motivation (Tabakoff and Hoffman, 2000) highlight limitations when using home-cage procedures.