We performed a GWA study, with replication of the top hit and genome-wide significant association in the meta-analysis across a total of 4088 patients and 11001 controls, including one sample from a different ethnic background. Together with gene expression data, neuroimaging correlates and evidence from a mouse model of chronic stress our results point towards SLC6A15, a neuronal amino acid transporter, as a novel candidate gene in the pathophysiology of major depression.
