the expense and availability of human oocytes. Finally, reprogramming approaches currently are only successful in ~10% of cells; thus, any neurons harboring highly aberrant genomes may be refractory to reprogramming. Despite these caveats, clonal reprogramming of human neurons is theoretically possible. In addition, it is noteworthy that mouse neurons reprogrammed by SCNT contain genomic rearrangements (e.g., kataegis and chromothripsis) that would be very challenging to validate using current WGA approaches (84).
