random samples; comparing numbers of cases accrued and those reported in the discharge records of the hospitals during the same time period to ensure that all consecutive cases were approached for the study; and verifying completeness of the database through multiple queries. Upon study completion, we developed a portal [19] for exchange of data, documents, timelines, meeting minutes, procedures, and draft manuscripts among investigators involved in the EAGLE data analyses, and a website [8] for public access to study design, collaborators, descriptive statistics, and publications.
