Chunk #54 — ONLINE METHODS — Secondary analyses in core PGC dataset — Summary-data-based Mendelian Randomization (SMR) analysis, FUSION and EpiXcan

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Mapping genomic loci implicates genes and synaptic biology in schizophrenia.

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We used FUSION44 and EpiXcan45 as tests of robustness of the SMR results. Details are supplied in the Supplementary Note as are our approaches to prioritising SMR associated genes.