Chunk #35 — Methods — Genome-wide genotyping array data sets used for evaluation of imputation quality and/or phenotype association analysis — Coronary Artery Risk Development in Young Adults (CARDIA)

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Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

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The CARDIA study is a longitudinal study of cardiovascular disease risk initiated in 1985–86 in 5,115 AA and European ancestry men and women, then aged 18–30 years. The CARDIA sample was recruited at four sites: Birmingham, AL, Chicago, IL, Minneapolis, MN, and Oakland, CA [54, 55]. Similar to JHS, genotyping was performed through the CARe consortium [52, 53] using an Affymetrix 6.0 array. In total, 1,619 AA participants with blood cell traits were included in the analysis.