Testing of these loci for association with T2D as a dichotomous trait in up to 40,655 cases and 87,022 non-diabetic controls demonstrated that the FG-raising alleles at seven loci (ADCY5, PROX1, GCK, GCKR and DGKB/TMEM195 and the known T2D genes TCF7L2 and SLC30A8), are robustly associated (P<5×10−8) with increased risk of T2D (Table 2); the association of a highly correlated SNP in ADCY5 with T2D in partially overlapping samples is reported by our companion manuscript29. We found less significant T2D associations (P<5×10−3) for variants in or near CRY2, FADS1, GLIS3 and FAM148B (Table 2). These data clearly show that loci with very similar FG effect sizes may have very different T2D risk effects (see for example ADCY5 and MADD in Table 2).
