Multiple SNPs on chromosome 3 near BCHE (butyrylcholinesterase) also displayed genome-wide significant association to cortical Aβ load (Figure 2). The peak association signal at this locus originated from rs509208 (p = 2.69 × 10−8), which is approximately 450 kb upstream (5′) of BCHE (Figure 3B). This association remained strong with the inclusion of APOE ε4 status as a covariate (p = 1.94 × 10−7).
