These data suggest both that this study has identified bona fide high-risk variants for autism spectrum disorders and that many of these loci also confer liability to a range of complex neurobehavioral phenotypes. They also suggest a more complex relationship of IQ and large de novo events than is often supposed: for example the relatively high rates of 16p11.2 and 7q11.23 CNVs and low rates of 15q11.2-13.1 duplications seen in this study compared to others may reflect particular subpopulations of rare de novo risk CNVs that are more readily ascertained in cohorts with higher mean IQ.
