Chunk #3 — CASE REPORT — PATIENTS AND CONTROL SUBJECTS

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Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation.

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Genomic DNA was extracted from blood samples with the use of the Puregene DNA kit (Gentra Systems). Paternity and maternity of each patient were confirmed with the use of six highly informative unlinked microsatellite markers (D2S1327, D3S1043, D4S3351, D6S1043, D8S1179, and D10S677).