Chitosan is a polysaccharide comprising copolymers of glucosamine and N-acetylglucosamine. Chitosan has been used as a dietary supplement for decreasing the body weight and lowering the cholesterol level [1]. It is a food additive and can be used as a flocculant and chelating agent for the clarification of beverages [2]. It is also a biodegradable carbohydrate polymer that has been widely used in the tissue engineering, wound healing, biosensers, and drug release [3]–[8]. Previous reports showed that chitosan exhibits anti-diabetic, hypocholesteromic, and blood glucose-lowering effects [9]–[11]. In vitro studies also suggested that chitosan inhibits adipogenesis and differentiation of adipocytes [12], [13]. However, the host response to chitosan and the target organs chitosan acted on remain to be clarified.
