Table S8; Supplementary Methods). Details of nominally significant results are given in Table 1. For rMDD only, there was a nominally significant (P=0.044) excess of minor alleles for SNPs with regulatory potential across all frequencies, and for rare SNPs in conserved regions with MAF ⩽0.18% (P=0.022). Nominally significant association was found in the LBC1936 data between the burden of minor alleles across all frequencies for SNPs in conserved transcription factor binding sites and increased symptoms of depression, a measure of depressed mood at the time of testing (Table 1). In addition, a nominally significant increase in burden of minor alleles for SNPs in CpG islands or coding SNPs was observed with Moray House Test scores, measures of cognitive ability (Supplementary Table S9). Summaries of the nominally significant results are given in Table 1.
