in molecular expression and function that do not alter basic cell features and can progressively change or be reversible over time. Comparable examples among neurons would be that of hippocampal pyramidal neurons and cerebellar Purkinje neurons, representing distinct neuronal subtypes, and each of these might exhibit state changes such as long term potentiation (LTP) or long term depression (LTD). Analogous concepts are needed, but do not yet exist for astrocytes or reactive astrocytes.
