Even with evidence showing a role for PPARs in oligodendrocyte regulation, conflicting data regarding the efficacy of these agonists on promoting OPC maturation or differentiation have been documented. In one study, undifferentiated C6 glioma cells were shown to up-regulate oligodendrocyte markers in response to agonists that target PPARγ, but not PPARδ or PPARα. In the same study, however, overexpression of PPARδ committed C6 cells to oligodendrocyte fate through the up-regulation of PPARγ (Leisewitz et al., 2008). These studies suggest that oligodendrocyte differentiation may depend on the coordinate activation of PPARs.
