it has been suggested that CELSR2 or SORT1 could be responsible for the reported associations of this locus with LDL [3], [24], [25]. In our data, the minor allele of rs629301 (a perfect tag of the lead SNP identified by GWAS), was associated with lower LDL-cholesterol (P = 2.6×10−4) and higher PRSC1 expression (P = 2.3×10−56) while PRSC1 expression and LDL-cholesterol were negatively correlated (P = 0.019). Results for CELSR2 were much less consistent and SORT1, the third gene at the locus, was not cis-modulated in monocytes.
