For the genome-wide significance threshold (p < 5e-8), at least 80% power to detect a SNP with effect size β=0.01 was not achieved under any combination of simulation parameters. For p < 5e-8, MAF=.5 and n=500,000 (the most well-powered combination of parameters) power to detect a SNP with effect size β=0.01 was 9%. For the suggestive threshold (p < 1e-5), at least 80% power to detect a SNP with effect size β=0.01 was not achieved under any combination of simulation parameters. For p < 1e-5, MAF=.50 and N=500,000 power to detect a SNP with effect size β=0.01 was 42% Power estimates for genome-wide significance (p < 5e-8) and suggestive significance (p < 1e-5) at varying values of MAF are presented for a SNP with effect size β=0.01 in Figure 6.
