The estimated heritability for TTTH1 was 0.31 ± 0.07 (p < 0.0001). The covariates age and max drinks accounted for approximately 15% of the phenotypic variance. A maximum LOD score of 4.24 was achieved at a point 156 cM from pter (see Figure 1). The region spanning 100 to 190 cM from pter exhibited evidence for linkage. A total of 395 SNPs (255 from Affymetrix and 140 from Illumina) fell into this region and were included in subsequent analyses.
