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Chunk #7 — OVERVIEW OF THE LATEST COEXPRESSION DATA — Increased number of common coexpression edges

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COXPRESdb in 2015: coexpression database for animal species by DNA-microarray and RNAseq-based expression data with multiple quality assessment systems.
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For drawing the coexpression network, we used the top three coexpressions for every gene as the coexpression edges. This coexpression threshold, three, was selected to achieve simpler virtualization of the network. Some coexpression edges repeatedly appear in different platforms, indicating the strong, highly reliable association of the gene pair. Such edges are highlighted in orange in NetworkDrawer, which is the coexpression network-drawing tool in COXPRESdb. An increase in the number of such commonly observed coexpression edges could be an indicator of favorable growth of the database. Therefore, we first summarized the number of edges commonly observed in the different platforms (Supplementary Data). To compare the platforms for different species, we used orthologous genes provided from HomoloGene (27). As expected, the number of commonly observed edges increased along with the higher data version. Especially, multiple platforms for the same species presented higher rate of common coexpression edges. For example, among the 7784 coexpression edges in the Dme platform, 1112 edges also appear in the Dme2 platform, but only 70 edges appear in the Hsa platform. When we focus on the platforms