The advances of the past 10 years raise many new questions to explore. The identification of ethanol binding sites on various GABAA receptor subtypes is yet unclear. The role of protein kinases and phosphatases in ethanol actions are limited to too few GABAA receptor subtypes. The coordinated actions of ethanol on multiple non-GABAergic targets that indirectly influence GABAergic neurotransmission seem too complex to untangle with physiological approaches. There is a lot of work to do.
