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Chunk #12 — MATERIALS AND METHODS — Post-fine-mapping QC

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CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies.
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Because some human genetic variants in 1KGP are not complete, there are variants without any LD information in some GWASs, which may markedly affect causal variant estimation in the process of fine-mapping. Thus, to avoid overestimation of causality for such variants, we excluded them (P-value > 5E−5) from the credible set, but still allowed users to inspect the original summary statistics. Also, for variants without LD information, we set the default PP value to −1. Since fine-mapping results may be inconsistent among three applied tools, we used rank product value to combine PP ranks for each credible set variant and prioritize the potential causal variants.