Chunk #20 — Materials and methods — Genotyping and CNV analysis — Gene set analyses — Statistical approaches

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De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

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To investigate the impact of using ‘control' CNVs, we undertook a random placement analysis comparing the number of de novo CNVs hitting each gene set with that found when CNV locations were randomised, importantly ensuring that each random assignment hits at least one gene, and that the probability of a gene being hit was proportional to its length (Supplementary Section 12).