Publicly available GWAS summary data across four blood lipids phenotypes was downloaded from public access websites [43]. Data was part of a meta-analysis conducted in individuals of European ancestry that examined four plasma lipid traits (number of significant loci): LDL cholesterol (14 loci), HDL cholesterol (37 loci), trigylcerides (23 loci), and total cholesterol (24 loci). From the original 2.0 M SNPs, we imputed an additional 5.3 million Z-scores using ImpG-Summary [34]. For each significant GWAS hit reported by Teslovich et al., we centered a 100 KB window on the lead SNP and estimated LD from the European reference panel of the 1 KG. We chose a conservative window of 50 Kb on either side of the GWAS hit, as it has been previously shown that within European populations, average LD decays after 25 KB [44]. These loci contained an average of 718 SNPs in the 1000 genomes reference panel, of which we were able to on average accurately impute 261 (see Table S9). This resulted in 2837 (10778), 1231 (3903), 1693 (5504), 1615 (5513) SNPs (with 1 KG imputation) to
