to drive both schizophrenia (Nieratschker et al., 2010) and addiction (Hyman et al., 2006). In extending ZNF804A SNP associations to heroin addiction, Sun et al. (in press) tested six ZNF804A SNPs in Han Chinese (N=3,922) and found that two of the most robust SNPs for psychosis were associated with heroin addiction, rs7597593 and rs1344706 (lowest uncorrected P=0.023 for single SNP tests and 0.0035 for their haplotype test). Both of these SNPs have also been implicated for regulating ZNF804A expression in postmortem human brain (Guella et al., 2014, Riley et al., 2010, Zhang et al., 2011), with rs1344706 being implicated specifically in the dorsolateral prefrontal cortex—a highly relevant brain region for addiction (Goldstein & Volkow, 2011). Our study focused on these two regulatory SNPs and tested their associations for independent replication with heroin addiction in 7,095 European Americans and 3,662 African Americans.
