Table I presents the false-positive error rate of the three trend tests of association over 5,000 replicates of data. Results are presented for a significance level of 5% over a range of FST, encompassing no divergence in allele frequencies between the case-control source population and the external cohorts (FST = 0), through to the level of differentiation expected between European and African populations. Also presented are mean maximum likelihood estimates of the allelic odds ratio, together with 5- and 95-percentiles across the 5,000 replicates of data.
